In recent studies on therapeutic architecture, the physical environment plays a decisive role in enhancing the healing process and strengthening patients’ hope for life. Prostate cancer, as one of the most prevalent diseases among men, requires spaces that, beyond fulfilling functional requirements, also address the psychological and emotional dimensions of treatment. This study aims to formulate a conceptual framework of Healing Architecture with a Life‑Hope orientation in prostate cancer treatment centers of Tonekabon City. The research adopts a qualitative–analytical methodology based on documentary studies conducted between 2019 and 2025, and the data are analyzed through the Environment–Perception–Behavior (EPB) model. The findings reveal a significant relationship between environmental elements (such as natural light and native vegetation), spatial perception (including homelike character and personal control), and patients’ adaptive behaviors, which ultimately lead to the emergence of the concept of Spatial Hope. The proposed model has been structured around eight localized quantitative design indicators adapted to the climate and culture of Tonekabon and demonstrates the potential for Post‑Occupancy Evaluation (POE) in real healthcare settings. This framework provides a scientific foundation for the localization of healing architectural principles and the enhancement of treatment quality within Iran’s healthcare system.